Cited skincare — peer-reviewed evidence, no upsell.
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Matrixyl

Palmitoyl Pentapeptide-4 · Palmitoyl Tetrapeptide-7 · Palmitoyl Tripeptide-1Active

Brand-name peptide complex marketed for collagen support. Modest in-vivo evidence over a 4–6 month window.

What it does

Matrixyl is a brand name (Sederma) for a family of palmitoylated signal peptides marketed as collagen-supporting actives. The original Matrixyl is palmitoyl pentapeptide-4; Matrixyl 3000 is a blend with palmitoyl tetrapeptide-7. In-vivo trials show measurable wrinkle-depth reduction over 4–6 months at typical concentrations — real but modest, comparable to vitamin C and well below retinoids on the same outcomes. Daily, consistent use is needed for the effect to surface.

The evidence, graded

expert consensusPeptides support collagen production through pathways distinct from retinoids. Combining the two can compound anti-aging benefits without compounding irritation.Mukherjee 2006 · Clinical Interventions in Aging ↗
emergingSome peptides are pH-sensitive and may degrade in acidic environments (low-pH AHA, BHA, or L-ascorbic acid). Apply at separate steps with a wait, or split into different times of day for stability.Errante 2020 · Frontiers in Chemistry ↗

Graded per the methodology: strong · moderate · emerging · expert consensus. A weak source on a strong claim gets the weaker label.

Also known as

palmitoyl pentapeptide-4, matrixyl 3000, pal-kttks

Pairs worth knowing

Niacinamide (Vitamin B3) · works together ↗Hyaluronic Acid · works together ↗Ceramides · works together ↗Retinol · works together ↗L-Ascorbic Acid (Vitamin C) · worth separating ↗
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